The volume and breadth of questions is amazing. The beta test, while challenging, has been a wonderful experience. Below are some example questions and, for brevity, I have simply add the clinical bottom line (NOTE: many of these will have been answered with a corpus lacking the majority of our systematic reviews so many are likely to be improved)

Treatment for Basedow Graves?
Clinical Bottom Line: The mainstays of treatment for Graves’ disease include antithyroid drugs, radioactive iodine, and surgical intervention, each with specific indications based on disease characteristics and patient preferences. Emerging therapies, such as monoclonal antibodies, offer promising future options, particularly for refractory cases or those with significant orbitopathy. A personalized approach, considering safety and patient-centric factors, is crucial for effective management.

What is the best treatment for binge eating disorders?
Clinical Bottom Line: For Binge Eating Disorder (BED), Cognitive Behavioral Therapy (CBT) remains the gold standard, supported by substantial evidence affirming its efficacy in reducing binge frequency and improving associated psychological outcomes. Pharmacotherapeutic options, such as lisdexamfetamine and naltrexone/bupropion, offer additional non-psychological avenues, particularly benefiting patients where BED coincides with obesity. Ultimately, a multidisciplinary approach tailored to individual needs—incorporating psychological, pharmacological, and possibly family-based interventions—is optimal for the management of BED.

Is type 2 diabetes mellitus a disease? What is the diseased organ if it is a disease?
Clinical Bottom Line: Type 2 diabetes mellitus is a complex metabolic disease involving multiple organs, primarily characterized by pancreatic β-cell dysfunction and insulin resistance across various tissues such as the liver, skeletal muscles, and adipose tissue, leading to systemic metabolic consequences.

Causes of septal panniculitis?
Clinical Bottom Line: Septal panniculitis encompasses a broad spectrum of diseases, chiefly characterized by etiologies involving inflammation of fat septa, either with or without vasculitis. Recognizing these underlying factors is imperative for targeted therapy and effective management.

What is the current evidence regarding nighttime dosing of antihypertensives? What is the rationale? What are the key trials regarding this? What are the current recommendations?
Clinical Bottom Line: While nighttime dosing of antihypertensive medications shows promise in certain contexts, overall evidence remains inconclusive. Current guidelines do not recommend routine switching to nighttime dosing, favoring individualized approaches based on patient needs and comprehensive BP management strategies.

In adult patients who have heart failure does providing early discharge teaching instead of current practice improve the 30-day readmission rate?
Clinical Bottom Line: Implementing early discharge education, particularly using interactive methods like the teach-back approach, significantly reduces 30-day readmission rates in heart failure patients compared to standard practice. Tailoring educational interventions to individual patient needs within a structured, multidisciplinary patient discharge plan is recommended to optimize outcomes and enhance self-management. Careful adoption of proven methods into practice will ensure better patient engagement, adherence, and overall health improvement.

Is niacinamide effective for primary or secondary prevention of skin cancer?
Clinical Bottom Line: Nicotinamide is beneficial for secondary prevention of non-melanoma skin cancers in high-risk patients, while its role in primary prevention warrants further investigation.