Last week marked a milestone for AskTrip; for the first time, we answered more than 500 clinical questions in a single week, reaching a new high of 542 questions answered.

Interestingly, the week began and ended with questions linked by a common theme – pain – yet illustrating the remarkable breadth of issues clinicians bring to AskTrip.

The first question of the week asked: What adverse effects might occur when carbamazepine and oxycodone are co-administered for pain management?

Here, the focus was on drug safety and interaction risk — a complex prescribing scenario involving multimorbidity, polypharmacy, and the need to balance analgesia with potential harms.

The final question of the week took us into a very different evidence space: What is the effectiveness of adding manual therapy to exercise therapy in reducing pain and disability in adults with chronic non-specific low back pain?

This reflects the non-pharmacological management of pain, where clinicians seek clarity on the value of physical and rehabilitative interventions supported by trials and systematic reviews.

Together, these two questions neatly capture what AskTrip is becoming known for – rapid, evidence-based answers across the full spectrum of clinical uncertainty. From medication safety to rehabilitation strategies, from individual prescribing decisions to broader questions of effectiveness, the diversity of questions continues to grow.

Surpassing 500 answers in a week is more than just a number. It reflects increasing trust from clinicians, expanding use at the point of care, and a widening recognition that high-quality evidence can, and should, be easier to access.

If this record week is any indication, the demand for fast, reliable clinical answers is only going in one direction.